PPM1B-ABCG8 Fusion FISH Probe
The PPM1B-ABCG8 Fusion FISH Probe is used to confirm a fusion of the PPM1B and ABCG8 genes. The fusion of the PPM1B and ABCG8 genes has been associated with Stomach Adenocarcinoma, and Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPM1B-ABCG8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-RERE | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-REOR | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-REGO | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-REGR | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-REAQ | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-ORRE | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-OROR | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-ORGO | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-GORE | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-GOOR | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-GOGO | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-GOGR | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-GRRE | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-GROR | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-GRGO | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-GRGR | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-AQRE | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-AQOR | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-AQGO | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-AQGR | 20 (40 μL) | 200 μL |
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| PPM1B-ABCG8-20-AQAQ | 20 (40 μL) | 200 μL |
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PPM1B Gene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1B
Chromosome: CHR2: 44395999 -44461742
Locus: 2p21
ABCG8 Gene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
Gene Name: ATP Binding Cassette Subfamily G Member 8
Chromosome: CHR2: 44066102 -44105605
Locus: 2p21
Gene Diseases
The PPM1B ABCG8 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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