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PPM1B-SRBD1 Fusion FISH Probe

The PPM1B-SRBD1 Fusion FISH Probe is used to confirm a fusion of the PPM1B and SRBD1 genes. The fusion of the PPM1B and SRBD1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PPM1B-SRBD1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PPM1B-SRBD1-20-RERE 20 (40 μL) 200 μL
PPM1B-SRBD1-20-REOR 20 (40 μL) 200 μL
PPM1B-SRBD1-20-REGO 20 (40 μL) 200 μL
PPM1B-SRBD1-20-REGR 20 (40 μL) 200 μL
PPM1B-SRBD1-20-REAQ 20 (40 μL) 200 μL
PPM1B-SRBD1-20-ORRE 20 (40 μL) 200 μL
PPM1B-SRBD1-20-OROR 20 (40 μL) 200 μL
PPM1B-SRBD1-20-ORGO 20 (40 μL) 200 μL
PPM1B-SRBD1-20-ORAQ 20 (40 μL) 200 μL
PPM1B-SRBD1-20-GORE 20 (40 μL) 200 μL
PPM1B-SRBD1-20-GOOR 20 (40 μL) 200 μL
PPM1B-SRBD1-20-GOGO 20 (40 μL) 200 μL
PPM1B-SRBD1-20-GOGR 20 (40 μL) 200 μL
PPM1B-SRBD1-20-GOAQ 20 (40 μL) 200 μL
PPM1B-SRBD1-20-GRRE 20 (40 μL) 200 μL
PPM1B-SRBD1-20-GROR 20 (40 μL) 200 μL
PPM1B-SRBD1-20-GRGO 20 (40 μL) 200 μL
PPM1B-SRBD1-20-GRGR 20 (40 μL) 200 μL
PPM1B-SRBD1-20-GRAQ 20 (40 μL) 200 μL
PPM1B-SRBD1-20-AQRE 20 (40 μL) 200 μL
PPM1B-SRBD1-20-AQOR 20 (40 μL) 200 μL
PPM1B-SRBD1-20-AQGO 20 (40 μL) 200 μL
PPM1B-SRBD1-20-AQGR 20 (40 μL) 200 μL
PPM1B-SRBD1-20-AQAQ 20 (40 μL) 200 μL

PPM1B Gene Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1B

Chromosome: CHR2: 44395999 -44461742

Locus: 2p21

SRBD1 Gene Summary

The S1 RNA Binding Domain 1 (SRBD1) gene is located on chr2 :45615818-45838433 at 2p21.

Gene Name: S1 RNA Binding Domain 1

Chromosome: CHR2: 45615818 -45838433

Locus: 2p21

Gene Diseases

The PPM1B SRBD1 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.