PPP1CC-KCNC2 Fusion FISH Probe
The PPP1CC-KCNC2 Fusion FISH Probe is used to confirm a fusion of the PPP1CC and KCNC2 genes. The fusion of the PPP1CC and KCNC2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1CC-KCNC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1CC-KCNC2-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNC2 Gene Summary
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: Potassium Voltage-gated Channel Subfamily C Member 2
Chromosome: CHR12: 75433895 -75603511
Locus: 12q21.1
PPP1CC Gene Summary
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Protein Phosphatase 1 Catalytic Subunit Gamma
Chromosome: CHR12: 111157612 -111180783
Locus: 12q24.11
Gene Diseases
The PPP1CC KCNC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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