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PPP1R12A-C12ORF26 Fusion FISH Probe

The PPP1R12A-C12ORF26 Fusion FISH Probe is used to confirm a fusion of the PPP1R12A and C12ORF26 genes. The fusion of the PPP1R12A and C12ORF26 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PPP1R12A-C12ORF26-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-RERE 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-REOR 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-REGO 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-REGR 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-REAQ 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-ORRE 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-OROR 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-ORGO 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-ORAQ 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-GORE 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-GOOR 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-GOGO 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-GOGR 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-GOAQ 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-GRRE 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-GROR 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-GRGO 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-GRGR 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-GRAQ 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-AQRE 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-AQOR 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-AQGO 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-AQGR 20 (40 μL) 200 μL
PPP1R12A-C12ORF26-20-AQAQ 20 (40 μL) 200 μL

PPP1R12A Gene Summary

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Gene Name: Protein Phosphatase 1 Regulatory Subunit 12A

Chromosome: CHR12: 80167342 -80329235

Locus: 12q21.2-q21.31

Gene Diseases

The PPP1R12A C12ORF26 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.