PPP1R12B-LGR6 Fusion FISH Probe
The PPP1R12B-LGR6 Fusion FISH Probe is used to confirm a fusion of the PPP1R12B and LGR6 genes. The fusion of the PPP1R12B and LGR6 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1R12B-LGR6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1R12B-LGR6-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP1R12B Gene Summary
Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 12B
Chromosome: CHR1: 202317829 -202557697
Locus: 1q32.1
LGR6 Gene Summary
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: Leucine Rich Repeat Containing G Protein-coupled Receptor 6
Chromosome: CHR1: 202163117 -202288889
Locus: 1q32.1
Gene Diseases
The PPP1R12B LGR6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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