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PPP2R4-PAX5 Fusion FISH Probe

The PPP2R4-PAX5 Fusion FISH Probe is used to confirm a fusion of the PPP2R4 and PAX5 genes. The fusion of the PPP2R4 and PAX5 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PPP2R4-PAX5-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PPP2R4-PAX5-20-RERE 20 (40 μL) 200 μL
PPP2R4-PAX5-20-REOR 20 (40 μL) 200 μL
PPP2R4-PAX5-20-REGO 20 (40 μL) 200 μL
PPP2R4-PAX5-20-REGR 20 (40 μL) 200 μL
PPP2R4-PAX5-20-REAQ 20 (40 μL) 200 μL
PPP2R4-PAX5-20-ORRE 20 (40 μL) 200 μL
PPP2R4-PAX5-20-OROR 20 (40 μL) 200 μL
PPP2R4-PAX5-20-ORGO 20 (40 μL) 200 μL
PPP2R4-PAX5-20-ORAQ 20 (40 μL) 200 μL
PPP2R4-PAX5-20-GORE 20 (40 μL) 200 μL
PPP2R4-PAX5-20-GOOR 20 (40 μL) 200 μL
PPP2R4-PAX5-20-GOGO 20 (40 μL) 200 μL
PPP2R4-PAX5-20-GOGR 20 (40 μL) 200 μL
PPP2R4-PAX5-20-GOAQ 20 (40 μL) 200 μL
PPP2R4-PAX5-20-GRRE 20 (40 μL) 200 μL
PPP2R4-PAX5-20-GROR 20 (40 μL) 200 μL
PPP2R4-PAX5-20-GRGO 20 (40 μL) 200 μL
PPP2R4-PAX5-20-GRGR 20 (40 μL) 200 μL
PPP2R4-PAX5-20-GRAQ 20 (40 μL) 200 μL
PPP2R4-PAX5-20-AQRE 20 (40 μL) 200 μL
PPP2R4-PAX5-20-AQOR 20 (40 μL) 200 μL
PPP2R4-PAX5-20-AQGO 20 (40 μL) 200 μL
PPP2R4-PAX5-20-AQGR 20 (40 μL) 200 μL
PPP2R4-PAX5-20-AQAQ 20 (40 μL) 200 μL

PAX5 Gene Summary

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Gene Name: Paired Box 5

Chromosome: CHR9: 36838530 -37034476

Locus: 9p13.2

Gene Diseases

The PPP2R4 PAX5 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Diffuse large B-cell lymphoma carrying t(9;14)(p13;q32)/PAX5-immunoglobulin heavy chain gene is characterized by nuclear positivity of MUM1 and PAX5 by immunohistochemistry

PAX5 encodes a transcription factor that helps regulate B-cell development. Rearrangements of the gene have been found in several low-grade B-cell tumors, including diffuse large B-cell lymphoma (DLBCL), where it’s frequently found fused to IGH. This study examined PAX5 expression in 4 DLBCL patients harboring PAX5/IGH fusions. Our PAX5 break-apart probe was used to confirm these fusions.