PPP4R2-FBXW7 Fusion FISH Probe
The PPP4R2-FBXW7 Fusion FISH Probe is used to confirm a fusion of the PPP4R2 and FBXW7 genes. The fusion of the PPP4R2 and FBXW7 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP4R2-FBXW7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-RERE | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-REOR | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-REGO | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-REGR | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-OROR | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-GORE | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-GROR | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP4R2-FBXW7-20-AQAQ | 20 (40 μL) | 200 μL |
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FBXW7 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Name: F-box And WD Repeat Domain Containing 7
Chromosome: CHR4: 153242409 -153456172
Locus: 4q31.3
PPP4R2 Gene Summary
The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Name: Protein Phosphatase 4 Regulatory Subunit 2
Chromosome: CHR3: 73046118 -73115011
Locus: 3p13
Gene Diseases
The PPP4R2 FBXW7 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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