PRAME-ACO2 Fusion FISH Probe
The PRAME-ACO2 Fusion FISH Probe is used to confirm a fusion of the PRAME and ACO2 genes. The fusion of the PRAME and ACO2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRAME-ACO2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PRAME-ACO2-20-AQAQ | 20 (40 μL) | 200 μL |
|
ACO2 Gene Summary
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Gene Name: Aconitase 2
Chromosome: CHR22: 41865128 -41924993
Locus: 22q13.2
PRAME Gene Summary
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Name: Preferentially Expressed Antigen In Melanoma
Chromosome: CHR22: 22890122 -22901696
Locus: 22q11.22
Gene Diseases
The PRAME ACO2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|