PRDM16-NARS2 Fusion FISH Probe
The PRDM16-NARS2 Fusion FISH Probe is used to confirm a fusion of the PRDM16 and NARS2 genes. The fusion of the PRDM16 and NARS2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRDM16-NARS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PRDM16-NARS2-20-AQAQ | 20 (40 μL) | 200 μL |
|
PRDM16 Gene Summary
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: PR/SET Domain 16
Chromosome: CHR1: 2985741 -3355185
Locus: 1p36.32
NARS2 Gene Summary
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). [provided by RefSeq, Mar 2015]
Gene Name: Asparaginyl-tRNA Synthetase 2, Mitochondrial
Chromosome: CHR11: 78147006 -78285909
Locus: 11q14.1
Gene Diseases
The PRDM16 NARS2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|