PRICKLE1-FGD4 Fusion FISH Probe
The PRICKLE1-FGD4 Fusion FISH Probe is used to confirm a fusion of the PRICKLE1 and FGD4 genes. The fusion of the PRICKLE1 and FGD4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRICKLE1-FGD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-RERE | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-REOR | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-REGO | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-REGR | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-REAQ | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-ORRE | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-OROR | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-ORGO | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-GORE | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-GOOR | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-GOGO | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-GOGR | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-GRRE | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-GROR | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-GRGO | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-GRGR | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-AQRE | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-AQOR | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-AQGO | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-AQGR | 20 (40 μL) | 200 μL |
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| PRICKLE1-FGD4-20-AQAQ | 20 (40 μL) | 200 μL |
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FGD4 Gene Summary
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Gene Name: FYVE, RhoGEF And PH Domain Containing 4
Chromosome: CHR12: 32655040 -32798984
Locus: 12p11.21
PRICKLE1 Gene Summary
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]
Gene Name: Prickle Planar Cell Polarity Protein 1
Chromosome: CHR12: 42852139 -42983572
Locus: 12q12
Gene Diseases
The PRICKLE1 FGD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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