PRKAA2-USP24 Fusion FISH Probe
The PRKAA2-USP24 Fusion FISH Probe is used to confirm a fusion of the PRKAA2 and USP24 genes. The fusion of the PRKAA2 and USP24 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKAA2-USP24-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-RERE | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-REOR | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-REGO | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-REGR | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-OROR | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-GORE | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-GROR | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKAA2-USP24-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKAA2 Gene Summary
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase AMP-activated Catalytic Subunit Alpha 2
Chromosome: CHR1: 57110989 -57181008
Locus: 1p32.2
USP24 Gene Summary
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
Gene Name: Ubiquitin Specific Peptidase 24
Chromosome: CHR1: 55532031 -55681039
Locus: 1p32.3
Gene Diseases
The PRKAA2 USP24 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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