PRKAR1A-FOXP1 Fusion FISH Probe
The PRKAR1A-FOXP1 Fusion FISH Probe is used to confirm a fusion of the PRKAR1A and FOXP1 genes. The fusion of the PRKAR1A and FOXP1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKAR1A-FOXP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-RERE | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-REOR | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-REGO | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-REGR | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-OROR | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-GORE | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-GROR | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKAR1A-FOXP1-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKAR1A Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
Gene Name: Protein Kinase CAMP-dependent Type I Regulatory Subunit Alpha
Chromosome: CHR17: 66508109 -66528910
Locus: 17q24.2
FOXP1 Gene Summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Forkhead Box P1
Chromosome: CHR3: 71004735 -71633140
Locus: 3p13
Gene Diseases
The PRKAR1A FOXP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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