PRKCA-PPP4R4 Fusion FISH Probe
The PRKCA-PPP4R4 Fusion FISH Probe is used to confirm a fusion of the PRKCA and PPP4R4 genes. The fusion of the PRKCA and PPP4R4 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKCA-PPP4R4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-RERE | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-REOR | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-REGO | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-REGR | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-OROR | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-GORE | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-GROR | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKCA-PPP4R4-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCA Gene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Alpha
Chromosome: CHR17: 64298925 -64806862
Locus: 17q24.2
PPP4R4 Gene Summary
The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. [provided by RefSeq, Jan 2017]
Gene Name: Protein Phosphatase 4 Regulatory Subunit 4
Chromosome: CHR14: 94640648 -94746072
Locus: 14q32.12-q32.13
Gene Diseases
The PRKCA PPP4R4 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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