PRKDC-CEP290 Fusion FISH Probe
The PRKDC-CEP290 Fusion FISH Probe is used to confirm a fusion of the PRKDC and CEP290 genes. The fusion of the PRKDC and CEP290 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKDC-CEP290-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-RERE | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-REOR | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-REGO | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-REGR | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-OROR | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-GORE | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-GROR | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKDC-CEP290-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKDC Gene Summary
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
Gene Name: Protein Kinase, DNA-activated, Catalytic Polypeptide
Chromosome: CHR8: 48685668 -48872743
Locus: 8q11.21
CEP290 Gene Summary
This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. [provided by RefSeq, Jul 2008]
Gene Name: Centrosomal Protein 290
Chromosome: CHR12: 88442789 -88535993
Locus: 12q21.32
Gene Diseases
The PRKDC CEP290 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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