PRLR-CDH12 Fusion FISH Probe
The PRLR-CDH12 Fusion FISH Probe is used to confirm a fusion of the PRLR and CDH12 genes. The fusion of the PRLR and CDH12 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRLR-CDH12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-RERE | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-REOR | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-REGO | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-REGR | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-REAQ | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-ORRE | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-OROR | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-ORGO | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-GORE | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-GOOR | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-GOGO | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-GOGR | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-GRRE | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-GROR | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-GRGO | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-GRGR | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-AQRE | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-AQOR | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-AQGO | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-AQGR | 20 (40 μL) | 200 μL |
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| PRLR-CDH12-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH12 Gene Summary
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 12
Chromosome: CHR5: 21750972 -22853731
Locus: 5p14.3
PRLR Gene Summary
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Gene Name: Prolactin Receptor
Chromosome: CHR5: 35055801 -35230823
Locus: 5p13.2
Gene Diseases
The PRLR CDH12 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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