PRMT1-TLE6 Fusion FISH Probe
The PRMT1-TLE6 Fusion FISH Probe is used to confirm a fusion of the PRMT1 and TLE6 genes. The fusion of the PRMT1 and TLE6 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRMT1-TLE6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-RERE | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-REOR | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-REGO | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-REGR | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-REAQ | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-ORRE | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-OROR | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-ORGO | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-GORE | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-GOOR | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-GOGO | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-GOGR | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-GRRE | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-GROR | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-GRGO | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-GRGR | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-AQRE | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-AQOR | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-AQGO | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-AQGR | 20 (40 μL) | 200 μL |
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| PRMT1-TLE6-20-AQAQ | 20 (40 μL) | 200 μL |
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PRMT1 Gene Summary
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Gene Name: Protein Arginine Methyltransferase 1
Chromosome: CHR19: 50180408 -50191704
Locus: 19q13.33
TLE6 Gene Summary
This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Gene Name: Transducin Like Enhancer Of Split 6
Chromosome: CHR19: 2977535 -2995182
Locus: 19p13.3
Gene Diseases
The PRMT1 TLE6 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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