PRUNE2-HDAC9 Fusion FISH Probe
The PRUNE2-HDAC9 Fusion FISH Probe is used to confirm a fusion of the PRUNE2 and HDAC9 genes. The fusion of the PRUNE2 and HDAC9 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRUNE2-HDAC9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-RERE | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-REOR | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-REGO | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-REGR | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-REAQ | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-ORRE | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-OROR | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-ORGO | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-GORE | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-GOOR | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-GOGO | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-GOGR | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-GRRE | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-GROR | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-GRGO | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-GRGR | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-AQRE | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-AQOR | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-AQGO | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-AQGR | 20 (40 μL) | 200 μL |
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| PRUNE2-HDAC9-20-AQAQ | 20 (40 μL) | 200 μL |
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HDAC9 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 9
Chromosome: CHR7: 18126571 -18708466
Locus: 7p21.1
PRUNE2 Gene Summary
The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Gene Name: Prune Homolog 2
Chromosome: CHR9: 79226291 -79521003
Locus: 9q21.2
Gene Diseases
The PRUNE2 HDAC9 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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