PSAP-C1S Fusion FISH Probe
The PSAP-C1S Fusion FISH Probe is used to confirm a fusion of the PSAP and C1S genes. The fusion of the PSAP and C1S genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSAP-C1S-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-RERE | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-REOR | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-REGO | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-REGR | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-REAQ | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-ORRE | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-OROR | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-ORGO | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-GORE | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-GOOR | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-GOGO | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-GOGR | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-GRRE | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-GROR | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-GRGO | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-GRGR | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-AQRE | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-AQOR | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-AQGO | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-AQGR | 20 (40 μL) | 200 μL |
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| PSAP-C1S-20-AQAQ | 20 (40 μL) | 200 μL |
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C1S Gene Summary
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
Gene Name: Complement C1s
Chromosome: CHR12: 7167979 -7178335
Locus: 12p13.31
PSAP Gene Summary
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Prosaposin
Chromosome: CHR10: 73576054 -73611082
Locus: 10q22.1
Gene Diseases
The PSAP C1S Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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