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PSAP-TYK2 Fusion FISH Probe

The PSAP-TYK2 Fusion FISH Probe is used to confirm a fusion of the PSAP and TYK2 genes. The fusion of the PSAP and TYK2 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PSAP-TYK2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PSAP-TYK2-20-RERE 20 (40 μL) 200 μL
PSAP-TYK2-20-REOR 20 (40 μL) 200 μL
PSAP-TYK2-20-REGO 20 (40 μL) 200 μL
PSAP-TYK2-20-REGR 20 (40 μL) 200 μL
PSAP-TYK2-20-REAQ 20 (40 μL) 200 μL
PSAP-TYK2-20-ORRE 20 (40 μL) 200 μL
PSAP-TYK2-20-OROR 20 (40 μL) 200 μL
PSAP-TYK2-20-ORGO 20 (40 μL) 200 μL
PSAP-TYK2-20-ORAQ 20 (40 μL) 200 μL
PSAP-TYK2-20-GORE 20 (40 μL) 200 μL
PSAP-TYK2-20-GOOR 20 (40 μL) 200 μL
PSAP-TYK2-20-GOGO 20 (40 μL) 200 μL
PSAP-TYK2-20-GOGR 20 (40 μL) 200 μL
PSAP-TYK2-20-GOAQ 20 (40 μL) 200 μL
PSAP-TYK2-20-GRRE 20 (40 μL) 200 μL
PSAP-TYK2-20-GROR 20 (40 μL) 200 μL
PSAP-TYK2-20-GRGO 20 (40 μL) 200 μL
PSAP-TYK2-20-GRGR 20 (40 μL) 200 μL
PSAP-TYK2-20-GRAQ 20 (40 μL) 200 μL
PSAP-TYK2-20-AQRE 20 (40 μL) 200 μL
PSAP-TYK2-20-AQOR 20 (40 μL) 200 μL
PSAP-TYK2-20-AQGO 20 (40 μL) 200 μL
PSAP-TYK2-20-AQGR 20 (40 μL) 200 μL
PSAP-TYK2-20-AQAQ 20 (40 μL) 200 μL

PSAP Gene Summary

This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Gene Name: Prosaposin

Chromosome: CHR10: 73576054 -73611082

Locus: 10q22.1

TYK2 Gene Summary

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

Gene Name: Tyrosine Kinase 2

Chromosome: CHR19: 10461203 -10491248

Locus: 19p13.2

Gene Diseases

The PSAP TYK2 Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Clear Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.