PSMC4-FRS2 Fusion FISH Probe
The PSMC4-FRS2 Fusion FISH Probe is used to confirm a fusion of the PSMC4 and FRS2 genes. The fusion of the PSMC4 and FRS2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSMC4-FRS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-RERE | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-REOR | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-REGO | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-REGR | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-REAQ | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-ORRE | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-OROR | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-ORGO | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-GORE | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-GOOR | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-GOGO | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-GOGR | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-GRRE | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-GROR | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-GRGO | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-GRGR | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-AQRE | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-AQOR | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-AQGO | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-AQGR | 20 (40 μL) | 200 μL |
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| PSMC4-FRS2-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMC4 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Proteasome 26S Subunit, ATPase 4
Chromosome: CHR19: 40477072 -40487353
Locus: 19q13.2
FRS2 Gene Summary
The Fibroblast Growth Factor Receptor Substrate 2 (FRS2) gene is located on chr12 :69864128-69973562 at 12q15.
Gene Name: Fibroblast Growth Factor Receptor Substrate 2
Chromosome: CHR12: 69864128 -69973562
Locus: 12q15
Gene Diseases
The PSMC4 FRS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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