PTPRS-ANGPTL4 Fusion FISH Probe
The PTPRS-ANGPTL4 Fusion FISH Probe is used to confirm a fusion of the PTPRS and ANGPTL4 genes. The fusion of the PTPRS and ANGPTL4 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTPRS-ANGPTL4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PTPRS-ANGPTL4-20-AQAQ | 20 (40 μL) | 200 μL |
|
PTPRS Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type S
Chromosome: CHR19: 5205518 -5340814
Locus: 19p13.3
ANGPTL4 Gene Summary
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
Gene Name: Angiopoietin Like 4
Chromosome: CHR19: 8429010 -8439257
Locus: 19p13.2
Gene Diseases
The PTPRS ANGPTL4 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|