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PTPRS-MBD3 Fusion FISH Probe

The PTPRS-MBD3 Fusion FISH Probe is used to confirm a fusion of the PTPRS and MBD3 genes. The fusion of the PTPRS and MBD3 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PTPRS-MBD3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PTPRS-MBD3-20-RERE 20 (40 μL) 200 μL
PTPRS-MBD3-20-REOR 20 (40 μL) 200 μL
PTPRS-MBD3-20-REGO 20 (40 μL) 200 μL
PTPRS-MBD3-20-REGR 20 (40 μL) 200 μL
PTPRS-MBD3-20-REAQ 20 (40 μL) 200 μL
PTPRS-MBD3-20-ORRE 20 (40 μL) 200 μL
PTPRS-MBD3-20-OROR 20 (40 μL) 200 μL
PTPRS-MBD3-20-ORGO 20 (40 μL) 200 μL
PTPRS-MBD3-20-ORAQ 20 (40 μL) 200 μL
PTPRS-MBD3-20-GORE 20 (40 μL) 200 μL
PTPRS-MBD3-20-GOOR 20 (40 μL) 200 μL
PTPRS-MBD3-20-GOGO 20 (40 μL) 200 μL
PTPRS-MBD3-20-GOGR 20 (40 μL) 200 μL
PTPRS-MBD3-20-GOAQ 20 (40 μL) 200 μL
PTPRS-MBD3-20-GRRE 20 (40 μL) 200 μL
PTPRS-MBD3-20-GROR 20 (40 μL) 200 μL
PTPRS-MBD3-20-GRGO 20 (40 μL) 200 μL
PTPRS-MBD3-20-GRGR 20 (40 μL) 200 μL
PTPRS-MBD3-20-GRAQ 20 (40 μL) 200 μL
PTPRS-MBD3-20-AQRE 20 (40 μL) 200 μL
PTPRS-MBD3-20-AQOR 20 (40 μL) 200 μL
PTPRS-MBD3-20-AQGO 20 (40 μL) 200 μL
PTPRS-MBD3-20-AQGR 20 (40 μL) 200 μL
PTPRS-MBD3-20-AQAQ 20 (40 μL) 200 μL

PTPRS Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Gene Name: Protein Tyrosine Phosphatase, Receptor Type S

Chromosome: CHR19: 5205518 -5340814

Locus: 19p13.3

MBD3 Gene Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Gene Name: Methyl-CpG Binding Domain Protein 3

Chromosome: CHR19: 1576677 -1592652

Locus: 19p13.3

Gene Diseases

The PTPRS MBD3 Fusion has been associated with the following diseases:

Disease Name
Esophageal Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.