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PTPRU-NOS1AP Fusion FISH Probe

The PTPRU-NOS1AP Fusion FISH Probe is used to confirm a fusion of the PTPRU and NOS1AP genes. The fusion of the PTPRU and NOS1AP genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PTPRU-NOS1AP-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-RERE 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-REOR 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-REGO 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-REGR 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-REAQ 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-ORRE 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-OROR 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-ORGO 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-ORAQ 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-GORE 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-GOOR 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-GOGO 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-GOGR 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-GOAQ 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-GRRE 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-GROR 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-GRGO 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-GRGR 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-GRAQ 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-AQRE 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-AQOR 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-AQGO 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-AQGR 20 (40 μL) 200 μL
PTPRU-NOS1AP-20-AQAQ 20 (40 μL) 200 μL

NOS1AP Gene Summary

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

Gene Name: Nitric Oxide Synthase 1 Adaptor Protein

Chromosome: CHR1: 162039580 -162339813

Locus: 1q23.3

PTPRU Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]

Gene Name: Protein Tyrosine Phosphatase, Receptor Type U

Chromosome: CHR1: 29563027 -29653325

Locus: 1p35.3

Gene Diseases

The PTPRU NOS1AP Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Clear Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.