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PUM1-HS2ST1 Fusion FISH Probe

The PUM1-HS2ST1 Fusion FISH Probe is used to confirm a fusion of the PUM1 and HS2ST1 genes. The fusion of the PUM1 and HS2ST1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PUM1-HS2ST1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PUM1-HS2ST1-20-RERE 20 (40 μL) 200 μL
PUM1-HS2ST1-20-REOR 20 (40 μL) 200 μL
PUM1-HS2ST1-20-REGO 20 (40 μL) 200 μL
PUM1-HS2ST1-20-REGR 20 (40 μL) 200 μL
PUM1-HS2ST1-20-REAQ 20 (40 μL) 200 μL
PUM1-HS2ST1-20-ORRE 20 (40 μL) 200 μL
PUM1-HS2ST1-20-OROR 20 (40 μL) 200 μL
PUM1-HS2ST1-20-ORGO 20 (40 μL) 200 μL
PUM1-HS2ST1-20-ORAQ 20 (40 μL) 200 μL
PUM1-HS2ST1-20-GORE 20 (40 μL) 200 μL
PUM1-HS2ST1-20-GOOR 20 (40 μL) 200 μL
PUM1-HS2ST1-20-GOGO 20 (40 μL) 200 μL
PUM1-HS2ST1-20-GOGR 20 (40 μL) 200 μL
PUM1-HS2ST1-20-GOAQ 20 (40 μL) 200 μL
PUM1-HS2ST1-20-GRRE 20 (40 μL) 200 μL
PUM1-HS2ST1-20-GROR 20 (40 μL) 200 μL
PUM1-HS2ST1-20-GRGO 20 (40 μL) 200 μL
PUM1-HS2ST1-20-GRGR 20 (40 μL) 200 μL
PUM1-HS2ST1-20-GRAQ 20 (40 μL) 200 μL
PUM1-HS2ST1-20-AQRE 20 (40 μL) 200 μL
PUM1-HS2ST1-20-AQOR 20 (40 μL) 200 μL
PUM1-HS2ST1-20-AQGO 20 (40 μL) 200 μL
PUM1-HS2ST1-20-AQGR 20 (40 μL) 200 μL
PUM1-HS2ST1-20-AQAQ 20 (40 μL) 200 μL

HS2ST1 Gene Summary

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Name: Heparan Sulfate 2-O-sulfotransferase 1

Chromosome: CHR1: 87380334 -87575681

Locus: 1p22.3

PUM1 Gene Summary

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Name: Pumilio RNA Binding Family Member 1

Chromosome: CHR1: 31404352 -31538564

Locus: 1p35.2

Gene Diseases

The PUM1 HS2ST1 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.