PXN-PLA2G1B Fusion FISH Probe
The PXN-PLA2G1B Fusion FISH Probe is used to confirm a fusion of the PXN and PLA2G1B genes. The fusion of the PXN and PLA2G1B genes has been associated with Esophageal Carcinoma, Adrenocortical Carcinoma, and Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PXN-PLA2G1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-RERE | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-REOR | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-REGO | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-REGR | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-REAQ | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-ORRE | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-OROR | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-ORGO | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-GORE | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-GOOR | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-GOGO | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-GOGR | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-GRRE | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-GROR | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-GRGO | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-GRGR | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-AQRE | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-AQOR | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-AQGO | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-AQGR | 20 (40 μL) | 200 μL |
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| PXN-PLA2G1B-20-AQAQ | 20 (40 μL) | 200 μL |
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PLA2G1B Gene Summary
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Gene Name: Phospholipase A2 Group IB
Chromosome: CHR12: 120759913 -120765592
Locus: 12q24.31
PXN Gene Summary
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Gene Name: Paxillin
Chromosome: CHR12: 120648241 -120703574
Locus: 12q24.23
Gene Diseases
The PXN PLA2G1B Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
| Adrenocortical Carcinoma |
| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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