QARS-USP19 Fusion FISH Probe
The QARS-USP19 Fusion FISH Probe is used to confirm a fusion of the QARS and USP19 genes. The fusion of the QARS and USP19 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| QARS-USP19-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-RERE | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-REOR | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-REGO | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-REGR | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-REAQ | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-ORRE | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-OROR | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-ORGO | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-ORAQ | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-GORE | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-GOOR | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-GOGO | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-GOGR | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-GOAQ | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-GRRE | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-GROR | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-GRGO | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-GRGR | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-GRAQ | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-AQRE | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-AQOR | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-AQGO | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-AQGR | 20 (40 μL) | 200 μL |
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| QARS-USP19-20-AQAQ | 20 (40 μL) | 200 μL |
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QARS Gene Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Name: Glutaminyl-tRNA Synthetase
Chromosome: CHR3: 49133364 -49142171
Locus: 3p21.31
USP19 Gene Summary
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Gene Name: Ubiquitin Specific Peptidase 19
Chromosome: CHR3: 49145478 -49158371
Locus: 3p21.31
Gene Diseases
The QARS USP19 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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