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R3HDM2-SORBS2 Fusion FISH Probe

The R3HDM2-SORBS2 Fusion FISH Probe is used to confirm a fusion of the R3HDM2 and SORBS2 genes. The fusion of the R3HDM2 and SORBS2 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
R3HDM2-SORBS2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-RERE 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-REOR 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-REGO 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-REGR 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-REAQ 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-ORRE 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-OROR 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-ORGO 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-ORAQ 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-GORE 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-GOOR 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-GOGO 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-GOGR 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-GOAQ 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-GRRE 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-GROR 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-GRGO 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-GRGR 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-GRAQ 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-AQRE 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-AQOR 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-AQGO 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-AQGR 20 (40 μL) 200 μL
R3HDM2-SORBS2-20-AQAQ 20 (40 μL) 200 μL

SORBS2 Gene Summary

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Name: Sorbin And SH3 Domain Containing 2

Chromosome: CHR4: 186506597 -186877870

Locus: 4q35.1

R3HDM2 Gene Summary

The R3H Domain Containing 2 (R3HDM2) gene is located on chr12 :57647547-57704246 at 12q13.3.

Gene Name: R3H Domain Containing 2

Chromosome: CHR12: 57647547 -57704246

Locus: 12q13.3

Gene Diseases

The R3HDM2 SORBS2 Fusion has been associated with the following diseases:

Disease Name
Glioblastoma Multiforme

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.