RAB1B-XBP1 Fusion FISH Probe
The RAB1B-XBP1 Fusion FISH Probe is used to confirm a fusion of the RAB1B and XBP1 genes. The fusion of the RAB1B and XBP1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAB1B-XBP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-RERE | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-REOR | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-REGO | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-REGR | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-REAQ | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-ORRE | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-OROR | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-ORGO | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-GORE | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-GOOR | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-GOGO | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-GOGR | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-GRRE | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-GROR | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-GRGO | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-GRGR | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-AQRE | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-AQOR | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-AQGO | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-AQGR | 20 (40 μL) | 200 μL |
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| RAB1B-XBP1-20-AQAQ | 20 (40 μL) | 200 μL |
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XBP1 Gene Summary
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Gene Name: X-box Binding Protein 1
Chromosome: CHR22: 29190547 -29196560
Locus: 22q12
RAB1B Gene Summary
Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]
Gene Name: RAB1B, Member RAS Oncogene Family
Chromosome: CHR11: 66036055 -66044963
Locus: 11q13.2
Gene Diseases
The RAB1B XBP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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