RAB2B-AZIN1 Fusion FISH Probe
The RAB2B-AZIN1 Fusion FISH Probe is used to confirm a fusion of the RAB2B and AZIN1 genes. The fusion of the RAB2B and AZIN1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAB2B-AZIN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-RERE | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-REOR | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-REGO | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-REGR | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-REAQ | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-ORRE | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-OROR | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-ORGO | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-GORE | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-GOOR | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-GOGO | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-GOGR | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-GRRE | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-GROR | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-GRGO | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-GRGR | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-AQRE | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-AQOR | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-AQGO | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-AQGR | 20 (40 μL) | 200 μL |
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| RAB2B-AZIN1-20-AQAQ | 20 (40 μL) | 200 μL |
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AZIN1 Gene Summary
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
Gene Name: Antizyme Inhibitor 1
Chromosome: CHR8: 103838535 -103876397
Locus: 8q22.3
RAB2B Gene Summary
Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]
Gene Name: RAB2B, Member RAS Oncogene Family
Chromosome: CHR14: 21927178 -21945132
Locus: 14q11.2
Gene Diseases
The RAB2B AZIN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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