RAB3GAP1-ACMSD Fusion FISH Probe
The RAB3GAP1-ACMSD Fusion FISH Probe is used to confirm a fusion of the RAB3GAP1 and ACMSD genes. The fusion of the RAB3GAP1 and ACMSD genes has been associated with Testicular Germ Cell Tumors, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAB3GAP1-ACMSD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-RERE | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-REOR | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-REGO | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-REGR | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-REAQ | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-ORRE | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-OROR | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-ORGO | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-GORE | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-GOOR | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-GOGO | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-GOGR | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-GRRE | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-GROR | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-GRGO | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-GRGR | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-AQRE | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-AQOR | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-AQGO | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-AQGR | 20 (40 μL) | 200 μL |
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| RAB3GAP1-ACMSD-20-AQAQ | 20 (40 μL) | 200 μL |
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RAB3GAP1 Gene Summary
This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Gene Name: RAB3 GTPase Activating Protein Catalytic Subunit 1
Chromosome: CHR2: 135809834 -135928279
Locus: 2q21.3
ACMSD Gene Summary
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
Gene Name: Aminocarboxymuconate Semialdehyde Decarboxylase
Chromosome: CHR2: 135596185 -135659602
Locus: 2q21.3
Gene Diseases
The RAB3GAP1 ACMSD Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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