RAB40C-MYH11 Fusion FISH Probe
The RAB40C-MYH11 Fusion FISH Probe is used to confirm a fusion of the RAB40C and MYH11 genes. The fusion of the RAB40C and MYH11 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAB40C-MYH11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-RERE | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-REOR | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-REGO | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-REGR | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-REAQ | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-ORRE | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-OROR | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-ORGO | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-GORE | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-GOOR | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-GOGO | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-GOGR | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-GRRE | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-GROR | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-GRGO | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-GRGR | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-AQRE | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-AQOR | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-AQGO | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-AQGR | 20 (40 μL) | 200 μL |
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| RAB40C-MYH11-20-AQAQ | 20 (40 μL) | 200 μL |
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MYH11 Gene Summary
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Myosin Heavy Chain 11
Chromosome: CHR16: 15796991 -15950887
Locus: 16p13.11
RAB40C Gene Summary
The RAB40C, Member RAS Oncogene Family (RAB40C) gene is located on chr16 :639356-679273 at 16p13.3.
Gene Name: RAB40C, Member RAS Oncogene Family
Chromosome: CHR16: 639356 -679273
Locus: 16p13.3
Gene Diseases
The RAB40C MYH11 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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