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RAB6A-MICA Fusion FISH Probe

The RAB6A-MICA Fusion FISH Probe is used to confirm a fusion of the RAB6A and MICA genes. The fusion of the RAB6A and MICA genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
RAB6A-MICA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
RAB6A-MICA-20-RERE 20 (40 μL) 200 μL
RAB6A-MICA-20-REOR 20 (40 μL) 200 μL
RAB6A-MICA-20-REGO 20 (40 μL) 200 μL
RAB6A-MICA-20-REGR 20 (40 μL) 200 μL
RAB6A-MICA-20-REAQ 20 (40 μL) 200 μL
RAB6A-MICA-20-ORRE 20 (40 μL) 200 μL
RAB6A-MICA-20-OROR 20 (40 μL) 200 μL
RAB6A-MICA-20-ORGO 20 (40 μL) 200 μL
RAB6A-MICA-20-ORAQ 20 (40 μL) 200 μL
RAB6A-MICA-20-GORE 20 (40 μL) 200 μL
RAB6A-MICA-20-GOOR 20 (40 μL) 200 μL
RAB6A-MICA-20-GOGO 20 (40 μL) 200 μL
RAB6A-MICA-20-GOGR 20 (40 μL) 200 μL
RAB6A-MICA-20-GOAQ 20 (40 μL) 200 μL
RAB6A-MICA-20-GRRE 20 (40 μL) 200 μL
RAB6A-MICA-20-GROR 20 (40 μL) 200 μL
RAB6A-MICA-20-GRGO 20 (40 μL) 200 μL
RAB6A-MICA-20-GRGR 20 (40 μL) 200 μL
RAB6A-MICA-20-GRAQ 20 (40 μL) 200 μL
RAB6A-MICA-20-AQRE 20 (40 μL) 200 μL
RAB6A-MICA-20-AQOR 20 (40 μL) 200 μL
RAB6A-MICA-20-AQGO 20 (40 μL) 200 μL
RAB6A-MICA-20-AQGR 20 (40 μL) 200 μL
RAB6A-MICA-20-AQAQ 20 (40 μL) 200 μL

RAB6A Gene Summary

This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Name: RAB6A, Member RAS Oncogene Family

Chromosome: CHR11: 73386682 -73472201

Locus: 11q13.4

MICA Gene Summary

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Name: MHC Class I Polypeptide-related Sequence A

Chromosome: CHR6_qbl_hap6: 2661006 -2676580

Locus: 6p21.33

Gene Diseases

The RAB6A MICA Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.