RAB7A-CLCN3 Fusion FISH Probe
The RAB7A-CLCN3 Fusion FISH Probe is used to confirm a fusion of the RAB7A and CLCN3 genes. The fusion of the RAB7A and CLCN3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAB7A-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| RAB7A-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
RAB7A Gene Summary
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]
Gene Name: RAB7A, Member RAS Oncogene Family
Chromosome: CHR3: 128444978 -128533641
Locus: 3q21.3
Gene Diseases
The RAB7A CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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