RAB8A-PLVAP Fusion FISH Probe
The RAB8A-PLVAP Fusion FISH Probe is used to confirm a fusion of the RAB8A and PLVAP genes. The fusion of the RAB8A and PLVAP genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAB8A-PLVAP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-RERE | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-REOR | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-REGO | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-REGR | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-REAQ | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-ORRE | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-OROR | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-ORGO | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-GORE | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-GOOR | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-GOGO | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-GOGR | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-GRRE | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-GROR | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-GRGO | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-GRGR | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-AQRE | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-AQOR | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-AQGO | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-AQGR | 20 (40 μL) | 200 μL |
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| RAB8A-PLVAP-20-AQAQ | 20 (40 μL) | 200 μL |
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RAB8A Gene Summary
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
Gene Name: RAB8A, Member RAS Oncogene Family
Chromosome: CHR19: 16222489 -16244445
Locus: 19p13.11
PLVAP Gene Summary
The Plasmalemma Vesicle Associated Protein (PLVAP) gene is located on chr19 :17462263-17488137 at 19p13.11.
Gene Name: Plasmalemma Vesicle Associated Protein
Chromosome: CHR19: 17462263 -17488137
Locus: 19p13.11
Gene Diseases
The RAB8A PLVAP Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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