RAB8B-TLN2 Fusion FISH Probe
The RAB8B-TLN2 Fusion FISH Probe is used to confirm a fusion of the RAB8B and TLN2 genes. The fusion of the RAB8B and TLN2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAB8B-TLN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-RERE | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-REOR | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-REGO | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-REGR | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-REAQ | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-ORRE | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-OROR | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-ORGO | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-GORE | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-GOOR | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-GOGO | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-GOGR | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-GRRE | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-GROR | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-GRGO | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-GRGR | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-AQRE | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-AQOR | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-AQGO | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-AQGR | 20 (40 μL) | 200 μL |
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| RAB8B-TLN2-20-AQAQ | 20 (40 μL) | 200 μL |
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RAB8B Gene Summary
RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]
Gene Name: RAB8B, Member RAS Oncogene Family
Chromosome: CHR15: 63481727 -63559973
Locus: 15q22.2
TLN2 Gene Summary
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Gene Name: Talin 2
Chromosome: CHR15: 62939509 -63136829
Locus: 15q22.2
Gene Diseases
The RAB8B TLN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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