RAD17-SEC24A Fusion FISH Probe
The RAD17-SEC24A Fusion FISH Probe is used to confirm a fusion of the RAD17 and SEC24A genes. The fusion of the RAD17 and SEC24A genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAD17-SEC24A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-RERE | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-REOR | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-REGO | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-REGR | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-REAQ | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-ORRE | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-OROR | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-ORGO | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-GORE | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-GOOR | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-GOGO | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-GOGR | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-GRRE | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-GROR | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-GRGO | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-GRGR | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-AQRE | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-AQOR | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-AQGO | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-AQGR | 20 (40 μL) | 200 μL |
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| RAD17-SEC24A-20-AQAQ | 20 (40 μL) | 200 μL |
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RAD17 Gene Summary
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
Gene Name: RAD17 Checkpoint Clamp Loader Component
Chromosome: CHR5: 68665123 -68710630
Locus: 5q13.2
SEC24A Gene Summary
The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: SEC24 Homolog A, COPII Coat Complex Component
Chromosome: CHR5: 133984478 -134063601
Locus: 5q31.1
Gene Diseases
The RAD17 SEC24A Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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