RAD9A-CLPB Fusion FISH Probe
The RAD9A-CLPB Fusion FISH Probe is used to confirm a fusion of the RAD9A and CLPB genes. The fusion of the RAD9A and CLPB genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAD9A-CLPB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-RERE | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-REOR | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-REGO | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-REGR | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-REAQ | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-ORRE | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-OROR | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-ORGO | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-GORE | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-GOOR | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-GOGO | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-GOGR | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-GRRE | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-GROR | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-GRGO | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-GRGR | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-AQRE | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-AQOR | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-AQGO | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-AQGR | 20 (40 μL) | 200 μL |
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| RAD9A-CLPB-20-AQAQ | 20 (40 μL) | 200 μL |
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RAD9A Gene Summary
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: RAD9 Checkpoint Clamp Component A
Chromosome: CHR11: 67159422 -67165883
Locus: 11q13.2
CLPB Gene Summary
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Name: ClpB Homolog, Mitochondrial AAA ATPase Chaperonin
Chromosome: CHR11: 72003469 -72145568
Locus: 11q13.4
Gene Diseases
The RAD9A CLPB Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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