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RAF1-IQSEC1 Fusion FISH Probe

The RAF1-IQSEC1 Fusion FISH Probe is used to confirm a fusion of the RAF1 and IQSEC1 genes. The fusion of the RAF1 and IQSEC1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
RAF1-IQSEC1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
RAF1-IQSEC1-20-RERE 20 (40 μL) 200 μL
RAF1-IQSEC1-20-REOR 20 (40 μL) 200 μL
RAF1-IQSEC1-20-REGO 20 (40 μL) 200 μL
RAF1-IQSEC1-20-REGR 20 (40 μL) 200 μL
RAF1-IQSEC1-20-REAQ 20 (40 μL) 200 μL
RAF1-IQSEC1-20-ORRE 20 (40 μL) 200 μL
RAF1-IQSEC1-20-OROR 20 (40 μL) 200 μL
RAF1-IQSEC1-20-ORGO 20 (40 μL) 200 μL
RAF1-IQSEC1-20-ORAQ 20 (40 μL) 200 μL
RAF1-IQSEC1-20-GORE 20 (40 μL) 200 μL
RAF1-IQSEC1-20-GOOR 20 (40 μL) 200 μL
RAF1-IQSEC1-20-GOGO 20 (40 μL) 200 μL
RAF1-IQSEC1-20-GOGR 20 (40 μL) 200 μL
RAF1-IQSEC1-20-GOAQ 20 (40 μL) 200 μL
RAF1-IQSEC1-20-GRRE 20 (40 μL) 200 μL
RAF1-IQSEC1-20-GROR 20 (40 μL) 200 μL
RAF1-IQSEC1-20-GRGO 20 (40 μL) 200 μL
RAF1-IQSEC1-20-GRGR 20 (40 μL) 200 μL
RAF1-IQSEC1-20-GRAQ 20 (40 μL) 200 μL
RAF1-IQSEC1-20-AQRE 20 (40 μL) 200 μL
RAF1-IQSEC1-20-AQOR 20 (40 μL) 200 μL
RAF1-IQSEC1-20-AQGO 20 (40 μL) 200 μL
RAF1-IQSEC1-20-AQGR 20 (40 μL) 200 μL
RAF1-IQSEC1-20-AQAQ 20 (40 μL) 200 μL

RAF1 Gene Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]

Gene Name: Raf-1 Proto-oncogene, Serine/threonine Kinase

Chromosome: CHR3: 12625099 -12705700

Locus: 3p25.2

IQSEC1 Gene Summary

The IQ Motif And Sec7 Domain 1 (IQSEC1) gene is located on chr3 :12938718-13114617 at 3p25.2-p25.1.

Gene Name: IQ Motif And Sec7 Domain 1

Chromosome: CHR3: 12938718 -13114617

Locus: 3p25.2-p25.1

Gene Diseases

The RAF1 IQSEC1 Fusion has been associated with the following diseases:

Disease Name
Bladder Urothelial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.