RAI14-MAPK9 Fusion FISH Probe
The RAI14-MAPK9 Fusion FISH Probe is used to confirm a fusion of the RAI14 and MAPK9 genes. The fusion of the RAI14 and MAPK9 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAI14-MAPK9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-RERE | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-REOR | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-REGO | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-REGR | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-REAQ | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-ORRE | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-OROR | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-ORGO | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-GORE | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-GOOR | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-GOGO | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-GOGR | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-GRRE | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-GROR | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-GRGO | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-GRGR | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-AQRE | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-AQOR | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-AQGO | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-AQGR | 20 (40 μL) | 200 μL |
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| RAI14-MAPK9-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK9 Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
Gene Name: Mitogen-activated Protein Kinase 9
Chromosome: CHR5: 179660594 -179719071
Locus: 5q35.3
RAI14 Gene Summary
The Retinoic Acid Induced 14 (RAI14) gene is located on chr5 :34656432-34832717 at 5p13.2.
Gene Name: Retinoic Acid Induced 14
Chromosome: CHR5: 34656432 -34832717
Locus: 5p13.2
Gene Diseases
The RAI14 MAPK9 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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