RANBP3-KLK2 Fusion FISH Probe
The RANBP3-KLK2 Fusion FISH Probe is used to confirm a fusion of the RANBP3 and KLK2 genes. The fusion of the RANBP3 and KLK2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RANBP3-KLK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-RERE | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-REOR | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-REGO | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-REGR | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-REAQ | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-ORRE | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-OROR | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-ORGO | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-GORE | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-GOOR | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-GOGO | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-GOGR | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-GRRE | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-GROR | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-GRGO | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-GRGR | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-AQRE | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-AQOR | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-AQGO | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-AQGR | 20 (40 μL) | 200 μL |
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| RANBP3-KLK2-20-AQAQ | 20 (40 μL) | 200 μL |
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KLK2 Gene Summary
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Kallikrein Related Peptidase 2
Chromosome: CHR19: 51376688 -51383823
Locus: 19q13.33
RANBP3 Gene Summary
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: RAN Binding Protein 3
Chromosome: CHR19: 5916151 -5978320
Locus: 19p13.3
Gene Diseases
The RANBP3 KLK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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