RANBP9-TPMT Fusion FISH Probe
The RANBP9-TPMT Fusion FISH Probe is used to confirm a fusion of the RANBP9 and TPMT genes. The fusion of the RANBP9 and TPMT genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RANBP9-TPMT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-RERE | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-REOR | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-REGO | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-REGR | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-REAQ | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-ORRE | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-OROR | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-ORGO | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-ORAQ | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-GORE | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-GOOR | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-GOGO | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-GOGR | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-GOAQ | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-GRRE | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-GROR | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-GRGO | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-GRGR | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-GRAQ | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-AQRE | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-AQOR | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-AQGO | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-AQGR | 20 (40 μL) | 200 μL |
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| RANBP9-TPMT-20-AQAQ | 20 (40 μL) | 200 μL |
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TPMT Gene Summary
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
Gene Name: Thiopurine S-methyltransferase
Chromosome: CHR6: 18128544 -18155374
Locus: 6p22.3
RANBP9 Gene Summary
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]
Gene Name: RAN Binding Protein 9
Chromosome: CHR6: 13621729 -13711796
Locus: 6p23
Gene Diseases
The RANBP9 TPMT Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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