RARA-CDC6 Fusion FISH Probe
The RARA-CDC6 Fusion FISH Probe is used to confirm a fusion of the RARA and CDC6 genes. The fusion of the RARA and CDC6 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RARA-CDC6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-RERE | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-REOR | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-REGO | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-REGR | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-REAQ | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-ORRE | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-OROR | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-ORGO | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-ORAQ | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-GORE | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-GOOR | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-GOGO | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-GOGR | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-GOAQ | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-GRRE | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-GROR | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-GRGO | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-GRGR | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-GRAQ | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-AQRE | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-AQOR | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-AQGO | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-AQGR | 20 (40 μL) | 200 μL |
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| RARA-CDC6-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC6 Gene Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Gene Name: Cell Division Cycle 6
Chromosome: CHR17: 38444145 -38459413
Locus: 17q21.2
RARA Gene Summary
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Gene Name: Retinoic Acid Receptor Alpha
Chromosome: CHR17: 38465422 -38513895
Locus: 17q21.2
Gene Diseases
The RARA CDC6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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