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RARA-PML Fusion FISH Probe

The RARA-PML Fusion FISH Probe is used to confirm a fusion of the RARA and PML genes. The fusion of the RARA and PML genes has been associated with Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, and Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
RARA-PML-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
RARA-PML-20-RERE 20 (40 μL) 200 μL
RARA-PML-20-REOR 20 (40 μL) 200 μL
RARA-PML-20-REGO 20 (40 μL) 200 μL
RARA-PML-20-REGR 20 (40 μL) 200 μL
RARA-PML-20-REAQ 20 (40 μL) 200 μL
RARA-PML-20-ORRE 20 (40 μL) 200 μL
RARA-PML-20-OROR 20 (40 μL) 200 μL
RARA-PML-20-ORGO 20 (40 μL) 200 μL
RARA-PML-20-ORAQ 20 (40 μL) 200 μL
RARA-PML-20-GORE 20 (40 μL) 200 μL
RARA-PML-20-GOOR 20 (40 μL) 200 μL
RARA-PML-20-GOGO 20 (40 μL) 200 μL
RARA-PML-20-GOGR 20 (40 μL) 200 μL
RARA-PML-20-GOAQ 20 (40 μL) 200 μL
RARA-PML-20-GRRE 20 (40 μL) 200 μL
RARA-PML-20-GROR 20 (40 μL) 200 μL
RARA-PML-20-GRGO 20 (40 μL) 200 μL
RARA-PML-20-GRGR 20 (40 μL) 200 μL
RARA-PML-20-GRAQ 20 (40 μL) 200 μL
RARA-PML-20-AQRE 20 (40 μL) 200 μL
RARA-PML-20-AQOR 20 (40 μL) 200 μL
RARA-PML-20-AQGO 20 (40 μL) 200 μL
RARA-PML-20-AQGR 20 (40 μL) 200 μL
RARA-PML-20-AQAQ 20 (40 μL) 200 μL

PML Gene Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Name: Promyelocytic Leukemia

Chromosome: CHR15: 74287013 -74340155

Locus: 15q24.1

RARA Gene Summary

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

Gene Name: Retinoic Acid Receptor Alpha

Chromosome: CHR17: 38465422 -38513895

Locus: 17q21.2

Gene Diseases

The RARA PML Fusion has been associated with the following diseases:

Disease Name
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.