RARA-SKAP1 Fusion FISH Probe
The RARA-SKAP1 Fusion FISH Probe is used to confirm a fusion of the RARA and SKAP1 genes. The fusion of the RARA and SKAP1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RARA-SKAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-RERE | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-REOR | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-REGO | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-REGR | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-OROR | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-GORE | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-GROR | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| RARA-SKAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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RARA Gene Summary
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Gene Name: Retinoic Acid Receptor Alpha
Chromosome: CHR17: 38465422 -38513895
Locus: 17q21.2
SKAP1 Gene Summary
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]
Gene Name: Src Kinase Associated Phosphoprotein 1
Chromosome: CHR17: 46210801 -46507594
Locus: 17q21.32
Gene Diseases
The RARA SKAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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