RARB-FAM19A4 Fusion FISH Probe
The RARB-FAM19A4 Fusion FISH Probe is used to confirm a fusion of the RARB and FAM19A4 genes. The fusion of the RARB and FAM19A4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RARB-FAM19A4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-RERE | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-REOR | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-REGO | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-REGR | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-REAQ | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-ORRE | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-OROR | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-ORGO | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-ORAQ | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-GORE | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-GOOR | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-GOGO | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-GOGR | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-GOAQ | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-GRRE | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-GROR | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-GRGO | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-GRGR | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-GRAQ | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-AQRE | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-AQOR | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-AQGO | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-AQGR | 20 (40 μL) | 200 μL |
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| RARB-FAM19A4-20-AQAQ | 20 (40 μL) | 200 μL |
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RARB Gene Summary
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: Retinoic Acid Receptor Beta
Chromosome: CHR3: 25469753 -25639422
Locus: 3p24.2
FAM19A4 Gene Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like
Chromosome: CHR3: 68780916 -68981711
Locus: 3p14.1
Gene Diseases
The RARB FAM19A4 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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