RARB-OSBPL10 Fusion FISH Probe
The RARB-OSBPL10 Fusion FISH Probe is used to confirm a fusion of the RARB and OSBPL10 genes. The fusion of the RARB and OSBPL10 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RARB-OSBPL10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-RERE | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-REOR | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-REGO | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-REGR | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-REAQ | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-ORRE | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-OROR | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-ORGO | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-ORAQ | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-GORE | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-GOOR | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-GOGO | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-GOGR | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-GOAQ | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-GRRE | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-GROR | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-GRGO | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-GRGR | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-GRAQ | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-AQRE | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-AQOR | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-AQGO | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-AQGR | 20 (40 μL) | 200 μL |
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| RARB-OSBPL10-20-AQAQ | 20 (40 μL) | 200 μL |
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RARB Gene Summary
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: Retinoic Acid Receptor Beta
Chromosome: CHR3: 25469753 -25639422
Locus: 3p24.2
OSBPL10 Gene Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Name: Oxysterol Binding Protein Like 10
Chromosome: CHR3: 31702316 -32023342
Locus: 3p23
Gene Diseases
The RARB OSBPL10 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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