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RASA1-FNIP1 Fusion FISH Probe

The RASA1-FNIP1 Fusion FISH Probe is used to confirm a fusion of the RASA1 and FNIP1 genes. The fusion of the RASA1 and FNIP1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
RASA1-FNIP1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
RASA1-FNIP1-20-RERE 20 (40 μL) 200 μL
RASA1-FNIP1-20-REOR 20 (40 μL) 200 μL
RASA1-FNIP1-20-REGO 20 (40 μL) 200 μL
RASA1-FNIP1-20-REGR 20 (40 μL) 200 μL
RASA1-FNIP1-20-REAQ 20 (40 μL) 200 μL
RASA1-FNIP1-20-ORRE 20 (40 μL) 200 μL
RASA1-FNIP1-20-OROR 20 (40 μL) 200 μL
RASA1-FNIP1-20-ORGO 20 (40 μL) 200 μL
RASA1-FNIP1-20-ORAQ 20 (40 μL) 200 μL
RASA1-FNIP1-20-GORE 20 (40 μL) 200 μL
RASA1-FNIP1-20-GOOR 20 (40 μL) 200 μL
RASA1-FNIP1-20-GOGO 20 (40 μL) 200 μL
RASA1-FNIP1-20-GOGR 20 (40 μL) 200 μL
RASA1-FNIP1-20-GOAQ 20 (40 μL) 200 μL
RASA1-FNIP1-20-GRRE 20 (40 μL) 200 μL
RASA1-FNIP1-20-GROR 20 (40 μL) 200 μL
RASA1-FNIP1-20-GRGO 20 (40 μL) 200 μL
RASA1-FNIP1-20-GRGR 20 (40 μL) 200 μL
RASA1-FNIP1-20-GRAQ 20 (40 μL) 200 μL
RASA1-FNIP1-20-AQRE 20 (40 μL) 200 μL
RASA1-FNIP1-20-AQOR 20 (40 μL) 200 μL
RASA1-FNIP1-20-AQGO 20 (40 μL) 200 μL
RASA1-FNIP1-20-AQGR 20 (40 μL) 200 μL
RASA1-FNIP1-20-AQAQ 20 (40 μL) 200 μL

RASA1 Gene Summary

The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]

Gene Name: RAS P21 Protein Activator 1

Chromosome: CHR5: 86564150 -86687733

Locus: 5q14.3

FNIP1 Gene Summary

This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

Gene Name: Folliculin Interacting Protein 1

Chromosome: CHR5: 130977406 -131132756

Locus: 5q31.1

Gene Diseases

The RASA1 FNIP1 Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.