RBBP8-ANXA4 Fusion FISH Probe
The RBBP8-ANXA4 Fusion FISH Probe is used to confirm a fusion of the RBBP8 and ANXA4 genes. The fusion of the RBBP8 and ANXA4 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RBBP8-ANXA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-RERE | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-REOR | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-REGO | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-REGR | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-REAQ | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-ORRE | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-OROR | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-ORGO | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-GORE | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-GOOR | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-GOGO | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-GOGR | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-GRRE | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-GROR | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-GRGO | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-GRGR | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-AQRE | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-AQOR | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-AQGO | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-AQGR | 20 (40 μL) | 200 μL |
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| RBBP8-ANXA4-20-AQAQ | 20 (40 μL) | 200 μL |
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ANXA4 Gene Summary
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
Gene Name: Annexin A4
Chromosome: CHR2: 69969126 -70053596
Locus: 2p13.3
RBBP8 Gene Summary
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Gene Name: RB Binding Protein 8, Endonuclease
Chromosome: CHR18: 20513294 -20606449
Locus: 18q11.2
Gene Diseases
The RBBP8 ANXA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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