RBBP8-TAF4B Fusion FISH Probe
The RBBP8-TAF4B Fusion FISH Probe is used to confirm a fusion of the RBBP8 and TAF4B genes. The fusion of the RBBP8 and TAF4B genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RBBP8-TAF4B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-RERE | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-REOR | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-REGO | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-REGR | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-REAQ | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-ORRE | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-OROR | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-ORGO | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-ORAQ | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-GORE | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-GOOR | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-GOGO | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-GOGR | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-GOAQ | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-GRRE | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-GROR | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-GRGO | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-GRGR | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-GRAQ | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-AQRE | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-AQOR | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-AQGO | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-AQGR | 20 (40 μL) | 200 μL |
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| RBBP8-TAF4B-20-AQAQ | 20 (40 μL) | 200 μL |
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RBBP8 Gene Summary
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Gene Name: RB Binding Protein 8, Endonuclease
Chromosome: CHR18: 20513294 -20606449
Locus: 18q11.2
TAF4B Gene Summary
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Gene Name: TATA-box Binding Protein Associated Factor 4b
Chromosome: CHR18: 23806408 -23971650
Locus: 18q11.2
Gene Diseases
The RBBP8 TAF4B Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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