RBM10-TFE3 Fusion FISH Probe
The RBM10-TFE3 Fusion FISH Probe is used to confirm a fusion of the RBM10 and TFE3 genes. The fusion of the RBM10 and TFE3 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RBM10-TFE3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-RERE | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-REOR | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-REGO | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-REGR | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-REAQ | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-ORRE | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-OROR | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-ORGO | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-ORAQ | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-GORE | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-GOOR | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-GOGO | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-GOGR | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-GOAQ | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-GRRE | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-GROR | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-GRGO | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-GRGR | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-GRAQ | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-AQRE | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-AQOR | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-AQGO | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-AQGR | 20 (40 μL) | 200 μL |
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| RBM10-TFE3-20-AQAQ | 20 (40 μL) | 200 μL |
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TFE3 Gene Summary
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: Transcription Factor Binding To IGHM Enhancer 3
Chromosome: CHRX: 48886241 -48900990
Locus: Xp11.23
RBM10 Gene Summary
This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]
Gene Name: RNA Binding Motif Protein 10
Chromosome: CHRX: 47004616 -47046214
Locus: Xp11.3
Gene Diseases
The RBM10 TFE3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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